痹痛宁颗粒抗炎镇痛的实验研究

Experimental studies on anti-inflammation and analgesic action of Bitongning granules

目的研究痹痛宁颗粒的抗炎镇痛作用。方法小鼠耳廓肿胀、大鼠足跖肿胀等实验观察其抗炎作用;通过热板法和醋酸扭体法观察其镇痛作用。结果痹痛宁颗粒能显者抑制二甲苯所致小鼠耳廓肿胀,蛋清致大鼠足跖肿胀,提高热板法疼痛模型小鼠痛阈值,抑制醋酸所致小鼠扭体痛反应。结论痹痛宁颗粒具有显著的抗炎、镇痛作用,应进—步深入探讨其抗炎、镇痛的作用机制。

OBJECTIVE To investigate the anti-inflammation and analgesic action of Bitongning granules. METHODS Observed the anti-inflammation by mouse auricular swelling, rat metatarsal swelling experiments; observed the analgesic action by mice hot-board and acetic-acid-induced twisting experiments. RESUTLS Bitongning granules had obivous inhibitory effect on mouse auricular swelling induced by dimethyl benzene and metatarsal swelling induced by albumen, elevated the pain threshold value of mice hot plate model, inhibited twisting reaction induced by acetic acid in mice. CONCLUSION Bitongning granules have obvious anti-inflammation and analgesic actions. We had better to investigate mechanism of the anti-inflammation and analgesic action.