摘要
从一株南海红树林青霉属真菌(No.2556)中分离得到6个化合物,利用波谱技术确定其结构分别为Sch54796(1),Sch 54794(2),对羟基苯甲酸(3),尿嘧啶(4),丁二酸(5),Vermopyrone(6)。化合物1、2、6为首次从青霉属中分离得到。活性测试表明化合物1和2对喉癌细胞hep 2抑制的IC50分别为9、33μg/ml,对肝癌细胞hepG2抑制抑制的IC50分别为17、25μg/ml,具有强细胞毒活性。
The metabolites of a marine mangrove fungus(Penicillium sp.No.2556) were studied in this paper and six compounds were isolated from the fermentation liquid.Their structures were elucidated by spectroscopy methods as Sch54796(1),Sch54794(2),4-hydroxybenzoic acid(3),urail(4),succinic acid(5),Vermopyrone(6).Among them,compounds 1,2 and 6 were firstly isolated from Penicillium sp.,Coumpouds 1 and 2 remarkably inhibited the growth of cancer cell lines hep2 and hepG2.
出处
《中药材》
CAS
CSCD
北大核心
2008年第7期960-962,共3页
Journal of Chinese Medicinal Materials
基金
国家863科技攻关计划资助项目(2003AA624010)
国家自然基金资助项目(20572136)
华南农业大学新学科及大型仪器使用基金(2006X013,2007Y006)
关键词
红树林真菌
代谢产物
青霉属
环二肽
细胞毒
Mangrove fungus
Metabolite
Penicillium sp.
Cyclodipeptide
Cytotoxic