一株红树林青霉属真菌(No.2556)活性代谢产物的研究

Secondary Metabolites of a Marine Mangrove Fungus(Penicillium sp.No.2556) From South China Sea

从一株南海红树林青霉属真菌(No.2556)中分离得到6个化合物,利用波谱技术确定其结构分别为Sch54796(1),Sch 54794(2),对羟基苯甲酸(3),尿嘧啶(4),丁二酸(5),Vermopyrone(6)。化合物1、2、6为首次从青霉属中分离得到。活性测试表明化合物1和2对喉癌细胞hep 2抑制的IC50分别为9、33μg/ml,对肝癌细胞hepG2抑制抑制的IC50分别为17、25μg/ml,具有强细胞毒活性。

The metabolites of a marine mangrove fungus（Penicillium sp.No.2556） were studied in this paper and six compounds were isolated from the fermentation liquid.Their structures were elucidated by spectroscopy methods as Sch54796（1）,Sch54794（2）,4-hydroxybenzoic acid（3）,urail（4）,succinic acid（5）,Vermopyrone（6）.Among them,compounds 1,2 and 6 were firstly isolated from Penicillium sp.,Coumpouds 1 and 2 remarkably inhibited the growth of cancer cell lines hep2 and hepG2.