Ang-2和VEGF在肾透明细胞癌中的表达及与肿瘤血管生成的关系

Expressing of Angiopoietin-2 and VEGF in Suprarenal Epithelioma and Their Relation to Tumor Angiogenesis

【目的】探讨Ang-2、VFGF及CD34在肾透明细胞癌中的表达及与肾透明细胞癌血管形成的关系。【方法】应用免疫组化S-P法,分别检测80例肾透明细胞癌组织及10例癌旁正常肾组织中Ang-2,VFGF及CD34的表达。【结果】肾透明细胞癌组织中Ang-2、VFGF阳性表达率分别为61.25%(49/80)、73.75%(59/80),均明显高于癌旁肾组织(P<0.01)。【结论】Ang-2对肿瘤血管生成的影响呈VFGF依赖性,Ang-2及VFGF在肾透明细胞癌血管生成中起协同促进作用。

[Objective]To investigate the expression of angiopoietin-2 （Ang-2）, vascular endothelial growth factor （VEGF） and CD34 in suprarenal epithelioma, and to evaluate the roles of Ang-2 and VEGF expression in the tumor angiogenesis. [Methods] The expression of Ang-2,VEGF and MVD were measured by immuno- histochemistry in tissue sections from 80 cases of suprarenal epithelioma and 10 cases of normal nephridial specimens. [Results]The positive rate for expression of Ang-2 and VEGF in suprarenal epithelioma was 61, 25% （49/80）and 73. 75% （59/80）, respectively, which was higher than that in normal nephridial tissue. [Conclusion] Ang-2 and VEGF may have a synergy with each other in angiogenesis of suprarenal epithelioma.