CD147蛋白表达与胆囊癌临床病理学的关系及意义

Association of CD147 Expression in Carcinoma of Gallbladder with Its Clinicopathological Features

【目的】探讨CD147蛋白在胆囊癌组织中的表达及其临床意义。【方法】选取胆囊癌患者112例，以慢性胆囊炎组织30例作为对照，应用SABC免疫组化方法检测CD147蛋白的表达。【结果】112例胆囊癌组织中CD147蛋白的阳性表达率为80.36％（90／112），明显高于在慢性胆囊炎组织中的阳性表达率（16.67％，5／30，P〈0．01）。CD147在低分化癌中非强阳性表达率高于中、高分化癌（P=0．02）；远端转移组的强阳性率高于无转移组（P〈0．01）；Nevin Ⅳ～Ⅴ期的强阳性表达率明显高于NevinⅠ～Ⅲ期的强阳性表达率（P-0．03）。【结论】CD147与胆囊癌的发生、浸润、转移有关，可作为新的胆囊癌标记物，具有重要的临床意义。

[Objective]To analyze the expression of CD147 in human carcinoma of gallbladder, and to evaluate its clinical significance in the progression of carcinoma of gallbladder, [Methods] A total of 112 patients with carcinoma of gallbladder were examined for the expression of CD147 by SABC immunohistochemistry. [Results] The positive expression rate of CD147 in 112 patients with carcinoma of gallbladder was 80.36% （90/112）, which was significantly higher than that in 30 cases of chronic cholecystitis （16.67%, 5/30, P〈 0. 01）. The strong positive rate of CD147 in poorly differentiated carcinoma of gallbladder increased dramatically comparing with that in moderately to well differentiated tissues （ P = 0. 02）, and the positive rate of CD147 in tumor tissues with distant metastasis was higher than that without metastasis （ P 〈0.01）, Among Nevin staging, the positive expression rate of CD147 in the stages of Ⅳ -Ⅴ was higher than that in Ⅰ - Ⅲ （ P =0.03）. [Conclusion] The expression of CD147 may be an important feature of carcinoma of gallbladder.