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肺小细胞癌组织中4.1蛋白家族的表达 被引量：3

Expression of protein 4.1 family in lung small cell carcinoma tissue
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摘要 目的:探讨肺小细胞癌组织中4.1蛋白家族的表达情况以及与淋巴结转移的关系。方法:取肺小细胞癌标本41例,采用免疫组织化学Envision+染色法检测4.1蛋白家族的表达情况。以21例癌旁正常组织作为对照。结果:肺小细胞癌组织中4.1R、4.1N和4.1G的阳性表达率低于癌旁正常组织(P<0.05),4.1B在2种组织中的表达差异无统计学意义(P>0.05);癌组织中4.1N、4.1G和4.1B的表达均与淋巴结转移无关(P>0.05),4.1R的表达与淋巴结转移有关(P<0.05)。结论:4.1蛋白家族成员在肺小细胞癌的发生、发展过程中作用不同。 Aim： To investigate the expression of protein 4. 1 family in lung small cell carcinoma（LSCC） tissue and its correlation with lymphnode metastasis. Methods ： Envision ＊ immunohistochemistry method was carried out to detect the expression of protein 4.1 family in 41 cases of LSCC tissues and 21 cases of paracarcinoma normal tissues. Results： The positive rates of 4.1R ,4.1N and 4. 1G in LSCC tissues were lower than that in the paracarcinoma normal tissues significant- ly （P〈0.05）. There was no correlation between the expression of 4. 1N,4. 1G,4. 1B and lymphnode metastasis（P 〉 0.05 ） except for 4.1R （ P 〈 0.05 ）. Conclusion ： 4. 1 N,4. 1G,4. 1B and 4. 1R maybe play important and different roles during the process of LSCC carcinogenesis.
作者 高艳锋 翟明霞 宋英 陈鲤翔 祁元明
机构地区 郑州大学生物工程系
出处 《郑州大学学报（医学版）》 CAS 北大核心 2008年第4期651-653,共3页 Journal of Zhengzhou University(Medical Sciences)
基金 河南省科技攻关基金资助项目0624410024 河南省高校杰出科研人才创新工程基金资助项目2007kycx002
关键词 小细胞癌 4.1蛋白 肺肿瘤 small cell carcinoma protein 4.1 lung cancer
分类号 R734.2 [医药卫生—肿瘤]
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参考文献12

  • 1Robb VA,Li W, Gascard P, et al. Identification of a third protein 4.1 tumor suppressor, protein 4.1 R,in meningioma pathogenesis [ J ]. Neurobiol Dis, 2003,13 ( 3 ) : 191.
  • 2Rajaram V, Gutmann DH, Prasad SK, et al. Alterations of protein 4.1 family members in ependymomas: a study of 84 cases[J]. Mod Pathol, 2005, 18(7) :991.
  • 3Kikuchi S, Yamada D, Fukami T, et al. Promoter methylation of DAL-1/4. 1B predicts poor prognosis in non-small cell lung cancer[J]. Clin Cancer Res, 2005, 11 (8) :2 954.
  • 4Kittinivom K ,Mastronardi M ,Roemer M ,et al. Allele-specific loss of heterozygosity at the DAL-1/4. 1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation [ J ]. Genes Chromosomes Cancer ,2004,40( 3 ) : 190.
  • 5赵焕芬,何春年.肺小细胞癌53例临床病理分析[J].诊断病理学杂志,2007,14(6):437-440. 被引量：20
  • 6潘琦,陈福春,陈洪雷,张玉霞,杨飞,夏东,刘铭球.人非小细胞肺癌组织中Survivin的表达及与caspase-3和p21^(WAF1)表达的意义[J].中华肿瘤防治杂志,2006,13(2):97-100. 被引量：12
  • 7Hoover KB, Bryant PJ. The genetics of the protein 4. 1 family : organizers of the membrane and cytoskeleton [ J ]. Curr Opin Cell Biol, 2000,12(2) :229.
  • 8Charboneau AL, Singh V, Yu T, et al. Suppression of growth and increased cellular attachment after expression of DAL-1 in MCF-7 breast cancer cells [ J]. Int J Cancer, 2002, 100(2) :181.
  • 9Gutmann DH, Hirbe AC, Huang ZY, et al. The protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion [ J ]. Neurobiol Dis, 2001, 8(2) :266.
  • 10Singh V,Miranda TB,Jiang W,et al. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo[J]. Oncogene,2004,23(47) :7 761.

二级参考文献82

共引文献33

同被引文献34

  • 1杜智勇,粟永萍.SRC-3基因敲除小鼠的饲养繁殖及鉴定[J].第三军医大学学报,2005,27(5):373-375. 被引量：6
  • 2赵玲,杜晓兰,苏楠,宋瑞华,何启芬,李福兵,戚华兵,陈林.HIF-1α条件性基因敲除嵌合体小鼠的获得[J].第三军医大学学报,2007,29(14):1361-1363. 被引量：4
  • 3Hoover KB,Bryant PJ.The genetics of the protein 4.1 family:organizers of the membrane and cytoskeleton[J].Curr Opin Cell Biol,2000,12(2):229-234.
  • 4Takakuwa Y.Protein 4.1,a muhifunctional protein of the erythrocyte membrane skeleton:structure and functions in erythrocytes and nonerythroid cells[J].Int J Hematol,2000,72(3):298-309.
  • 5Tran YK,Bogler O,Gorse KM,et al.A novel member of the NF2/ERM/4.1 supeffamily with growth suppressing properties in lung cancer[J].Cancer Res,1999,59(1):35-43.
  • 6Gutmann DH,Donahoe J,Perry A,et al.Loss of DAL-1,aprotein 4.1-related tumor suppressor,is an important early event in the pathogenesis of meningiomas[J].Hum Mol Genet,2000,9(10):1495-1500.
  • 7Heller G,Geradts J,Ziegler B,et at.Down regulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer[J].Breast Cancer Res Treat,2007,103(3):283-291.
  • 8Wong SY,Haack H,Kissil JL et al.Protein 4.1B supprsses prostate cancer progression and metastasis[J].Proc Natl Acad Sci USA,2007,104(31):12784-12789.
  • 9Yamada D,Kikuchi S,Williams YN,et al.Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma[J].lnt J Cancer,2006,118(4):916-923.
  • 10Cavanna T,Pokomá E,Vesely P,et al.Evidence for protein 4.1B acting as a metastasis suppressor[J].J Cell Sci,2007,120(Pt 4):606-616.

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郑州大学学报（医学版）
2008年 第4期

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