窒息新生儿尿转铁蛋白和β_2微球蛋白水平测定

Determination of urinary transferrin and β_2-microglobulin of newborns with asphyxia

目的:观察窒息新生儿尿转铁蛋白(TRF)及β2微球蛋白(β2-MG)水平的变化。方法:取51例窒息新生儿(轻度窒息30例,重度窒息21例)及206例正常新生儿生后第1次及生后24h尿液,检测TRF、β2-MG;同时取血,测血尿素氮(BUN)、肌酐(Cr)。结果:窒息组2次尿TRF及β2-MG异常率及表达水平均较正常组明显升高(P<0.05);与重度窒息组比较,轻度窒息组第1次尿TRF及β2-MG水平及异常率较低(P<0.05),而第2次结果2组差异无统计学意义(P>0.05)。结论:尿TRF及β2-MG是反映窒息新生儿早期肾小球和肾小管功能改变的敏感性指标。

Aim： To observe the changes of the Urinary Transferrin （TRF） and β2-microglobulin（β2-MG） of the new- born with asphyxia, Methods ： A Total of 51 cases of newborns with asphyxia and 206 cases of normal infants were subjected to measure TRF and β2-MG in the first urine and 24 hours after birth, Urine nitrogen （BUN） and creatinine （Cr） were also detected at the same time in asphyxia group. Results：Abnormal rates and the levels of urine TRF and β2-MG in asphyxia group were significantly higher than those of the control group （ P 〈 0.05 ）. The levels and the abnormal rates of urine TRF and β2-MG in the mild asphyxia group were lower than those of the severe asphyxia group, but there was no significant difference in the second time （P 〉 O. 05 ）. Conclusion： Urine TRF and β2 -MG were sensitive indicators in the reflection of early neonatal asphyxia glomerular and tubular function.