急性心肌梗死合并糖尿病患者血清细胞凋亡因子sFas和sFasL的变化及意义

Change and significance of the sera apoptotic cytokines sFas and sFasL in patients with acute myocardial infarction and diabetes mellitus

目的了解糖尿病对急性心肌梗死患者血清细胞凋亡因子sFas和sFasL的影响。方法急性心肌梗死患者根据是否合并糖尿病将其分为非糖尿病组和糖尿病组。应用ELISA方法测定两组患者血清sFas和sFasL的含量。结果AMI合并DM患者血清sFas和sFasL的浓度明显高于非糖尿病患者,P<0.01。心功能killip3/4级患者血清sFas和sFasL的浓度也高于killip1、2级患者,P<0.05。结论急性心肌梗死合并糖尿病患者血清细胞凋亡因子sFas和sFasL的浓度高于非糖尿病患者。糖尿病可能通过促进Fas/FasL系统的激活而加速急性心肌梗死时心肌细胞凋亡的发生。

Objective To examine the effects of diabetes mellitus on the apoptotic cytokines of sFas and sFasL in the sera of patients with AMI. Methods Patients with AMI were divided into two groups： no diabetes mellitus and diabetes mellitus based on whether accompanied DM or not. Strepavidin-biotin ELISA was used to determine the serum levels of sFas and sFasL. Results The concentrations of sFas and sFasL in the sera of patients with AMI and DM were much higher than those of the patients who were AMI with no diabetes mellitus, P〈0.01. The concentrations of sFas and sFasL in the sera of the patients with killip3/4 were respectively higher than those of the patients with killip1、2, P〈0.05. Conclusion The concentrations of the apoptotic cytokines sFas and sFasL in the sera of the patients with AMI and DM are higher than those of the patients with AMI and no diabetes mellitus. Diabetes mellitus may accelerate cardiomyocytes apoptosis through activation of Fas/FasL system in patients with acute myocardial infarction.