黏蛋白抗原4与肿瘤的相关研究进展

Progress about Relationship between MUC4 and Tumour

黏蛋白抗原4(MUC4)是一跨膜的黏附分子,近来发现在人体许多组织、器官中都有表达,与胰腺癌的发病机制有关,超乎常规地表达于其他上皮性肿瘤,并与肿瘤细胞的生长、浸润、转移相关。卵巢上皮性肿瘤早期诊断困难,MUC4可能与其发生、发展有关。MUC4可作为肿瘤早期诊断和预后的分子标志物,为治疗提供了新方向。

MUC4 is a transmembrane adhesion molecule. Recent studies show that it not only expressed in many tissues and organs of the body and is related to the pathogenesis of pancreatic cancer,but also is over expressed on the other epithelial tumors and is related to the growth, invasion and metastasis tumors. It is difficult to diagnose the epithelial tumor of ovary early, and MUC4 maybe related to the genesis and development of this kind of tumor. MUC4 can be concerned as molecular marker of the early diagnosis and prognosis of tumor and provide new direction for the therapy.