血清前清蛋白判断肺结核患者肝损伤的临床价值

Clinical value of serum prealbumin in pulmonary tuberculosis patients with liver damage

目的探讨血清前清蛋白(PA)判断肺结核患者肝损伤的临床价值。方法采用免疫透射比浊法分别检测152例肺结核患者和40例健康体检者PA,同时检测丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)作对比分析。结果肺结核患者血清PA测定值(217.5±84.9)mg/L,明显低于健康对照组测定值(316.4±84.9)mg/L,差异有统计学意义(t=7.044,P<0.001),而ALT和AST的测定值肺结核患者与健康对照组比较差异无统计学意义(t=1.685、0.806,P>0.05)。肺结核患者血清PA的异常率为39.5%,明显高于ALT(13.1%)及AST(9.8%)的异常率,差异有统计学意义(χ2=27.14、35.84,P<0.01)。结论血清PA对判断结核患者早期肝功能损伤有重要意义,其敏感性优于ALT和AST。

Objective To explore the clinical application of serum prealbumin （PA） in pulmonary tuberculosis patients with liver damage. Methods Immunoturbidimetry assay was applied to measuring serum prealbumin （PA） in 152 pulmonary tuberculosis patients （TB group） and 40 healthy controls （control group）. Simultaneously, serum ALT and AST were measured. The test results were compared and analyzed. Results Serum level of PA was significantly lower in TB group than that of control group [（217. 5±84. 9） vs （316.4±84.9） mg/L] （t=7.044,P〈0.001）. There wasn＇t statistical difference between the two groups in serum level of ALT and AST （t =1. 685, 0. 806;P〉0.05）. The abnormity rate of serum PA （39.5%） was significantly higher than that of ALT （13. 1%） and AST （9.8%） in TB group （χ^2 =27. 14, 35.84;P〈0.01）. Conclosion Serum PA has important clinical sigficance in judging early liver damage in pulmonary tuberculosis patients, and its sensitivity is superior to that of ALT and AST.