米菲司酮的关键中间体的合成改进

Synthesis of Two Key Intermediates of Mifepristone

化合物Ⅱ、Ⅴ是合成抗早孕药物米菲司酮的两个关键中间体，本文以二氧戊环交换反应法合成了化合物Ⅱ，以“一锅煮”法合成化合物Ⅴ，改进后的合成方法具有收率高、操作简单及适合工业化生产等优点。

Compound Ⅱ and compound Ⅴ are two key intermediates of a new antiprogesterone drug Mifepristone. Compound Ⅱ was synthesized by dioxolane exchange reaction, and compound Ⅴ was prepared through repeated Grignard reaction successively in 'one pot'. The new methods have the advantages of high yield, easy operation and satisfaction of the needs of industrial production.