部分脾栓塞术联合脾动脉灌注长春新碱治疗难治性ITP和Evans综合征的临床研究

PARTIAL SPLLEN EMBOLIZATION COMBINED WITH VINCRISTINE INFUSION IN TREATING IDIOPATHIC THROMBOCYTOPENIC PURPURA AND EVANS SYNDROMES

目的探讨难治性特发性血小板减少性紫癜(ITP)和Evans综合征新的有效治疗方法。方法对我院2000～2006年收治的难治性ITP和Evans综合征患者56例,随机分为两组,治疗组30例,对照组26例。两组病人均采用部分脾栓塞术治疗,治疗组在栓塞前给予脾动脉灌注长春新碱(2 mg)。结果两组患者暂时疗效(术后1月)相比较差异无显著性(P>0.05)。近期疗效(术后6个月)和远期疗效(术后2年)相比较差异有显著性(P均<0.05)。结论部分脾栓塞术联合脾动脉灌注长春新碱治疗难治性ITP和Evans综合征,具有"1+1"大于"2"的良好疗效。

Objective To study a new treatment of for idiopathic thrombocytopenic purpura （ITP） and Evans syndromes. Methods 56 patients suffering from idiop thrombbocytopenic purpura and Evans syndromes adopted in our department from 2000to 2006 were divided into two groups randomly, New treatment of partial spleen embolization combined with spleen artery vincristine in fusion was given to 30 cases of patients and other 26 cases received only partial spleen embolization as the control group. Results The transient curative effects within one month in two groups had no significant difference while the difference of treatment effects between short （6 moth） and long （2 year） terms was significant. Conclusion Partial spleen embolization can produce better curative effects if combined with vincristine to treat ITP and Evans syndromes.