氟哌啶醇与泰必利治疗多发性抽动综合征的近期疗效评价

Short-Term Effects of Holoperidol and Tiapride on Tourette Syndrome

本文分别以多巴胺受体阻滞剂氟哌啶醇及泰必利治疗多发性抽动综合征（TS）患者共103例。其中氟哌啶醇治疗组计71例，总有效率80．3％。但该药副作用较多，影响治疗进行，认为从小剂量开始、剂量个体化以及用抗震颤麻痹药安坦等有助于防止副作用发生。泰必利治疗组计30例，总有效率76．7％，与氟哌啶醇比较疗效无显著性差异；优点在于副作用少，随访中仅1例有嗜睡发生。认为泰必利与氟哌啶醇相比有一定优越性，可优先选用。

Dopamine recepter antagonists were given to 103 patients with TouretteSyndrome (TS) in this paper. Haloperidol was used to treat 71 patients, the total effective rate was 80.3% Unfortunately, 30 patients suffered fromextrapyramidal side effects which could impede treatment, including sonmolence (17 cases), stuppor (9 cases), acute dystonic reaction (2 cas es), insonmia (1 cases),blurred vision (1 case). We confirmed that starting with low dose, individualixing dosage and adding Artane day was benefit. Tiapride was used to treat 30 patients. The total effective rate was 76.7%.There was nosignificant difference between the two drugs effectiveness. And Tiapride had advantage of few side effects, there was only one patient showed somnolence in our study. As a result, we confirmed that Tiapride will be the first chosenfor TS.