三七皂甙对大鼠海马脑片缺氧损伤的保护作用

The Protective Effect of Rg1 on Hippocampal Slices of Rats in Anoxic Condition

采用大鼠海马脑片缺氧模型，从细胞水平上探讨三七皂甙（Ｒｇ１）对神经细胞缺氧损伤的保护作用及其机理。实验结果显示，Ｒｇ１能提高神经细胞的耐缺氧能力，并对神经细胞缺氧损伤具有明显的保护作用，其作用机制与Ｒｇ１拮抗钙离子内流和对抗谷氨酸的毒性作用有密切关系。

In the study,rat hippocampal slices were employed to investigate the effect of Rg1 and its mechanism of preventing neurons from being damaged in anoxic condition.The results show that Rg1could increase the ability of neurons for cenduing anoxic condition and protect neurons against injuring. Its mechanism is that Rg1 decreases the Ca2+ influx and abates the toxic effect of Clutamic acid.