肝毒净颗粒剂提取-浓缩-喷雾干燥相关工艺因素的正交实验研究

Orthogonal Experiments on Extract-concentrate-spray drier Related Technological Factors for Gandujing Granule

采用正交试验法，以投料药材的干粉得率和干粉的总蒽醌含量为考核指标，对肝毒净颗粒剂所采用的“提取—浓缩—喷雾干燥”工艺与药材煎煮时间，煎煮次数，加水量，欲干燥药物清膏的相对密度，喷雾干燥器进风温度及出风温度等主要工艺因素的相关性进行研究，为优选该制剂的生产工艺提供依据。

By using orthogonal tests, the ratio of dry powder obtained from crude drugs and the total anthrquinone content of powder as criteria, the correlation among the “Extract-concentrate-spray drier” technology for Gandujing granule and the main technological factors such as time and frequency of decoction,volume of water, relative density of extract, the in_temperature and out_temperature of spray drier, etc. was studied. It provided a scientific basis for the optimal production technology of the preparation.