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GDNF在脑疾病中研究进展

Progress in Study of the GDNF in Brain Diseases
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摘要 胶质细胞源性神经营养因子是近年来发现的一种蛋白质,特异性保护多巴胺能神经元,增加乙酰胆碱转移酶的活性,促进损伤后感觉及运动神经元的再生,对抗谷氨酸所致的神经元变性。在脑缺血性疾病中治疗效果持不同见解。近年研究显示外源性GDNF对多种神经疾病有神经保护作用,现就这一方面的研究做一综述。 Glial cell line-derived neurotrophic factor purified in recent years is a specific neuroprotective factor for dopaminergic neurons, upregulates acylcholine acylhydrolase, enhances survival of injured sensory neurons and motor neurons, modifies glutamatemediated degeneration. Different opinions exist in brain isehemia. Exogenous glial cell line-derived neurotrophic factor shows neuroprotective effect in central nervous diseases, this review focuses on these progresses.
作者 马长永 马春明
机构地区 山东省临朐县中医院 潍坊医学院解剖教研室
出处 《医学信息》 2008年第8期1472-1473,共2页 Journal of Medical Information
关键词 GDNF 胶质细胞源性神经营养因子 脑疾病 多巴胺能神经元 乙酰胆碱转移酶 脑缺血性疾病 神经保护作用 特异性保护
分类号 R651.2 [医药卫生—外科学] R742 [医药卫生—神经病学与精神病学]
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参考文献13

  • 1[1]Lin LF,Doherty DH,Lile JD,et al.GDNF:a gliai cell line-derived neurotrophic factor for midbrain dopaminergic neurons.Science,1993,260:1130-2.
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医学信息
2008年 第8期

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