降黏合剂预防冠心病经皮腔内冠脉成形术后再狭窄的临床研究

THE PREVENTIVE EFFECTS OFON RE-STRICTURE VICOSITY-REDUCTION MIXTURE AFTER PERCUTANEOUS INTRACAVITARY PLASTIC OPERATION

目的探讨降黏合剂预防冠心病经皮腔内冠脉成形术后再狭窄的临床疗效。方法将69例行经皮腔内冠脉成形术成功的冠心病患者随机分为两组,治疗组36例,在西药常规治疗的基础上加用降黏合剂治疗,对照33例采用西药常规治疗,疗程均为4个月,追踪观察患者有无心绞痛复发、血瘀症状和血瘀证候积分的变化,并通过冠状动脉造影复查评价再狭窄的发生。结果治疗组复查14例,狭窄2例,再狭窄率为14.2%。对照组复查12例,狭窄3例,再狭窄率为25%,两组比较有统计学意义(P<0.05)。治疗组患者在随访中各项血瘀症状均有明显的改善,4个月后血瘀证候积分值明显下降,与对照组比较有显著性差异(P<0.05)。结论降黏合剂预防冠心病经皮腔内冠脉成形术后再狭窄有较好作用。

Objective To explore the curative effects of viscosity-reduction mixture on re-stricture after percutaneous intracavitary plastic operation. Methods Of the 69 cases, 36 case formed the treatment group treated with viscosity-reduction mixture in addition to routine treatment of western medicine, and 33 cases formed the contrast group treated with routine treated. The course of treatment lasted 4 months in both groups. Angina pectoris, stasis of blood and symptom integral values were observed and coronary arteriography was made to evaluate the occurrence of re-stricture. Results Re-examinations discovered 2 cases of re-stricture （14.2%） in the treatment group and 3 cases of re-stricture （25%） in the contrast group （ P 〈0.05）. The follow-up surveys found that the symptom integral values declined obviously 4 months later. There existed significant differences between the two groups （ P 〈0.05）. Conclusion Viscosit-reduction mixture can produce good curative effects on re-stricture after percutaneous intracavitary plastic operation.