摘要
目的探讨老年高血压患者颈动脉内膜中层厚度(IMT)与胰岛素抵抗的关系。方法测定260例老年高血压患者(HT组)、23例老年高血压合并2型糖尿病患者(HT+DM组)和250名健康体检者(NC组)的动态血压、血空腹血糖(FBG)、空腹胰岛素(FINS)、甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)及体重指数(BMI),并运用高分辨率B型超声仪检测受试者的颈动脉IMT。结果3组BMI、血压(包括SBP、DBP)、血脂(包括TG、IC、HDL)的差异均无统计学意义(P>0.05);HT组FBG、FINS、IM均显著高于NC组(P<0.05或0.01),而IAI显著低于NC组(P<0.01);HT+DM组FBG、FINS、IMT均显著高于HT组及NC组(P<0.05或0.01),而IAI显著低于HT组及NC组(P<0.05或0.01)。IMT与BMI、FBG呈显著正相关,与IAI呈显著负相关(均P<0.01)。结论老年高血压患者颈动脉IMT高于正常人,而且与高血压患者胰岛素抵抗的发生、发展密切相关。
Objective To investigate the relationship between intima-media thickness of carotid artery(IMT)and insulin resistance( IR)in elderly hypertensive patients. Methods Two hundred sixty elderly hypertensive patients (HP group) ,230 elderly hypertensive patients with type 2 diabetes mellitus (HP+DM group) and 250 healthy individuals (NC group) were enrolled in the study. The levels of Ambulatory blood pressure monitoring (ABPM), fasting blood glucose (FBG), fasting insulin (FINS), triglyceride (TG), Plasma-cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and Body Mass Index (BMI) were measured in three groups. IMT of carotid was examined with high-resolution ultrasonography. Results There were significant differences in FBG, FINS, IMT, Insulin sensitivity index (IAI) among three groups. The IMT was positively correlated with BMI and FBG; negatively correlated with IAI. Conclusion The IMT in elderly hypertensive patients are higher than that of the healthy individuals, which are significantly associated with the development of IR.
出处
《浙江医学》
CAS
2008年第7期680-681,684,共3页
Zhejiang Medical Journal
关键词
高血压
颈动脉内膜中层厚度
胰岛素抵抗
Hypertension Intima-media thickness of carotid Insulin resistance