摘要
观察了20例恶性肿瘤患者血清对正常人自然杀伤细胞（NKC）活性的影响，发现荷瘤者血清可使正常人NKC活性明显抑制，其抑制率达78.9％，伴转移癌患者血清的抑制率明显高于不伴转移者。同时证实，癌症患者血清NKC抑制因子活性可被消炎痛部分阻断，而一定剂量的白细胞介素-2则无明显阻断作用，提示癌症患者血清存在的NKC抑制因子与肿瘤的发生发展密切相关，其本质可能是多因素的。
The influece of serum in 80 malignant tumors cases to natural killer cell (NKC) activity of normal controls was studied.The results showed serum of tumor-bearing patients sup pressed 78. 9% of normal control NKC activity. This serum suppressive activity in the patients with matastatic tumors were apparently higher than those without - metastases. Otherwise,this suppressive activity could be partly blocked by in domethacin, hut not by smalll dose recombinant interleukin2. So it may suggest that serum NKC suppressive factor in tumor - bearing patients was closely related with developing and advancing of malignant tumors, however it's essence might might be multifarious.
关键词
肿瘤
癌
自然杀伤细胞
免疫抑制因子
Neoplasm, Natural killer cell, Immune suppressive factor, Indomethacin, Interleukin-2
