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Fas/FasL及Bcl-2在胃癌组织表达相关性及临床意义 被引量：2

EXPRESSION OF Fas,FasL AND Bcl-2 IN GASTRIC CANCER AND ITS SIGNIFICANCE
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摘要 目的:探讨Fas、FasL、Bcl-2在胃癌组织中的表达及其相关性。方法:应用免疫组化技术S-P染色法对20例正常胃组织和72例胃癌组织进行Fas、FasL、Bcl-2蛋白表达,光密度测定进行统计检测。结果:高、中分化胃腺癌中Fas蛋白表达显著高于低分化腺癌(P<0.05),Bcl-2蛋白表达在高分化腺癌中显著低于低分化腺癌(P<0.05)。本组Fas与Bcl-2呈负相关(r=-0.391)。结论:Fas、FasL、Bcl-2蛋白表达失衡与胃癌的进展及预后密切相关。对于胃癌的诊疗具有一定的实用价值。 Objective： To study the expression of Fas, FasL and Bcl - 2 in gastric cancer and its significance. Methods：20 cases of normal gastric mucosa,72 cases of gastric cancer were examined with immunohistochemistry technique. Results：The expression of Fas in well differentiated cancer was higher than that in poorly differentiated cancer（P 〈 0. 05 ）. The expressions of Fas and Bcl -2 protein were negatively correlated（ r = -0. 391 ）. Conclusion： Fas may be helpful in predicting the prognosis of patients. Imbalance of Bcl - 2 and Fas expression may correlate with gastric cancer.
作者 梁俊国 高旭东 朱宪明 靳智勇 孙嘉阳
机构地区 内蒙古医学院附属医院胸心外科
出处 《内蒙古医学院学报》 2008年第2期80-83,共4页 Acta Academiae Medicinae Neimongol
基金 内蒙古卫生厅项目(2006028)
关键词 胃癌 FAS FASL BCL-2 凋亡 gastric cancer Fas FasL Bcl - 2 apoptosis
分类号 R735.2 [医药卫生—肿瘤]
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共引文献76

同被引文献23

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  • 2杨小明,陈永昌,陈钧,谢吉民.银杏中银杏酸诱导人白血病细胞U937凋亡的研究[J].食品科学,2006,27(9):241-246. 被引量：10
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内蒙古医学院学报
2008年 第2期

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