新型人TNFα对小鼠Lewis肺癌的抗肿瘤作用

Anti tumor effects of a new TNFα variative on murine Lewis lung cancer

本文研究了一种重组人ＴＮＦα衍生物（ｒｈＴＮＦαＤ１１ａ）对小鼠Ｌｅｗｉｓ肺癌的抗肿瘤作用。同时与原型重组人ＴＮＦα（ｒｈＴＮＦα）的抗肿瘤作用进行了比较，并对它们全身给药和局部给药的抗瘤效果作了对比。Ｃ５７ＢＬ／６小鼠接种肿瘤细胞后ｄ７，将ｒｈＴＮＦαＤ１１ａ和ｒｈＴＮＦα以高、中、低三种剂量分别连续肌肉注射４ｄ，或瘤内注射３ｄ，停药后１ｄ处死动物，根据抑瘤率进行疗效评价。结果表明，ｒｈＴＮＦαＤ１１ａ各剂量组的抑瘤率均显著高于同样剂量的ｒｈＴＮＦα；两种ＴＮＦ瘤内注射的抗肿瘤作用均明显优于肌肉注射。

In this paper, we observed the anti tumor effects of a new TNFα variative (rhTNF αD11a) on murine Lewis lung cancer. C57BL/6 mice were implanted with cancer cells and tumor developed at the 7 th day. Different doses of rhTNFα D11a or natural TNF α were injected intramuscularly for 4 days or intra tumor for 3 days. Mice were slaughted 1 day later, and the effects were estimated by the tumor depression ratio. It showed that the tumor depression ratio of every rhTNF α D11a dose was significantly higher than that of natural rhTNF α. Furthermore, intra tumor injection was superior to intramuscular way.