胃癌患者血清表皮生长因子的变化

Alteration of serum epidermal growth factor in gastric cancer patients

目的探讨人血清表皮生长因子（ｈＥＧＦ）水平与胃癌的关系．方法胃癌患者３３例，男３０例，女３例，年龄３５岁～８１岁，平均６４９岁；慢性胃炎患者３８例，男２５例，女１３例，年龄１８岁～７５岁，平均４３２岁；正常人２０例，男１０例，女１０例．应用ＲＩＡ法检测血清中的ｈＥＧＦ．结果胃癌组血清ｈＥＧＦ（μｇ／Ｌ）为１３５±０６７，正常对照组为０９０±０３３，统计学差异非常显著（ｔ＝２８２５，Ｐ＜００１），慢性胃炎组血清ｈＥＧＦ为０８６±０３３，与正常对照组比较差异无显著性（ｔ＝０４１，Ｐ＞００５）．结论胃癌患者血清ｈＥＧＦ水平升高可能与胃癌发生密切相关．

IM To study the alteration of epidermal growth factor (EGF) in serum of patients with gastric cancer. METHODS Serum EGF was measured in 33 gastric cancer patients (M 30, F 3) aged from 35 to 81 years (mean age 649 years), 38 chronic gastritis patients (M 25, F 13), aged from 18-75 years (mean age 432 years) and 20 healthy adults (M 10, F 10) by radioimmunoassay method. RESULTS Serum EGF levels (μg/L) were significantly higher in gastric cancer patients (135±067) than normal controls (090±033), (t=2825,P<001). But there was no difference between chronic gastritis patients (086±033) and normal control groups (t=0410,P>005). CONCLUSION Serum EGF might play a crucial role in the development of gastric cancer.