三维适形放疗治疗非小细胞肺癌35例疗效观察

Clinical Analysis of 3-Dimensional Conformal Radiation Therapy for 35 Cases with Non-Small Cell Lung Cancer

目的评价三维适形放射治疗肺癌的疗效。方法对35例肺癌采用三维适形放射治疗，其中男性19例，女性16例，年龄36～80岁，中位年龄66岁。设3～5个共面等中心照射野，80％-90％的等剂量线包绕PTV，靶区包括肿瘤边缘外0．5～1．5em，用6MVX线照射，总量为DT43．2～54Gy，2．25～3．6Cy／次，5次／周。放疗结束后1～2月复查CT。结果本组35例，CR5例（14．28％），PR20例（57．14％），SD9例（25．71％），PD1例（2．86％），有效率CR＋PR为71．43％。结论三维适形放射治疗适用于肺癌的治疗，毒副反应小，效果明显。

Objective To evaluate the effects of three-dimensional conformal radiation therapy for lung carcinoma. Methods From August 2003 to July 2007 35 cases with lung carcinoma were treated with three-dimensional conformal. 19 were men, 16 were women, mean age 66, range from 36 to 80. Irradiation fielded had 3 -5, 80% -90% isodose line included PTV. The total radiation dose of 43.2 -54 Gy, 2.25 3.6 Gy/F, 5 F/W. For 3-DCRT, radiation was given by 6 MV-X. Results In all the patients, the overall response rate was 71.43 %. There were 5（14.28% ） complete response （CR）, 20（57.14% ） partial response （PR）, 9（25.71% ） stable response （SD）, 1（2.86% ） progressive response （PD）. Conclusion 3-DCRT was feasible in the treatment of lung carcinoma, with good immediate tumor response, and milder toxicity.