陕西省肾综合征出血热疫苗中期效果评价及免疫增强的研究

Evaluation on Long-term Efficacy of Vaccines against HFRS and Study of Antihody-dependent Enhancement

观察两种HFRS灭活疫苗在陕西省高发病区接种后第2年的免疫效果。方法：于加强免疫前及免疫后14天、1年采集接种者静脉血，应用微量细胞病变法和荧光法检测中和抗体、IgG抗体，并观察流行病学防病效果。结果：鼠脑纯化灭活疫苗（Ⅰ型）加强免疫1年后，中和抗体阳性率为45％，GMT5．41，接种组无发病者，而对照组发病率为79．10／10万，保护率100％；沙鼠肾灭活疫苗（Ⅰ型）中和抗体阳性率40％，GMT50，接种组发病率6．02／10万，对照组发病率108．41／10万，保护率94．45％。两种疫苗均末发现免疫增强反应。

This article reported the immunization efficacy of 2 kinds HFRS vaccines in the end year after the inoculating in Shanxi province. For the mouse brain vaccine, the ghtive rate of neutralizing antithey one year's after the enhancement inoculation was 45 %, geometric mean titer (GMT) was 5.41, the incidence rates were 0 and 79. 10/ 100, 000 for inoculation group and contro group, so the protection rate was 100 %. For the Meriones unguiculatus kidney vaccine, the opitive rate of neutralizing antithey one year's after the enhancement inoculation was 40 % 1 GMT was 5. 0, the incidentS for inoculation group and control group were 6. 02/100, 000 and 108. 41/100, 000, the protectbo rate was 94. 45 %.There was no evidence to prove the existing of antibody-dependent enhancement.