摘要
目的研究慢性阻塞性肺疾病(COPD)患者不同病期血浆尾加压素Ⅱ(UⅡ)、肾上腺髓质素(ADM)含量的变化,从人体水平探讨低氧对UⅡ合成和释放的影响,以及UⅡ和ADM在COPD中的相互关系及意义;为深入研究COPD发病机制开拓新思路,并将为防治COPD提供新策略。方法采用放射免疫分析法(RIA)检测COPD急性加重期患者、稳定期患者和健康对照组的血浆UⅡ、ADM、动脉血氧分压(PaO2)及肺动脉压(PAP)的变化,并进行统计学分析。结果3组患者PAP、PaO2、血浆UⅡ及ADM含量间比较差异均有统计学意义(P<0.01)。COPD患者血浆UⅡ含量和PaO2呈负相关(P<0.05),与PAP呈正相关(P<0.05)。COPD患者血浆UⅡ和ADM含量呈正相关。结论UⅡ作为缩血管因子,可能参与了HPH的形成,UⅡ血浆含量增加的同时,出现ADM含量增加是机体的一个自我保护机制。
Objective To study the content changes of plasma urotensin Ⅱ （ U Ⅱ ） and adrenomedullin （ADM） in patients with chronic obstructive pulmonary disease （COPD） at different stages of disease so as to investigate the impact of hypoxia on synthesis and release of U Ⅱ , and the relationship between U Ⅱ and ADM and its significance, with a purpose of opening a new thinking way of pathogenesis of COPD and providing a new strategy for prevention and treatment of COPD. Methods The radioimmunoassay （RIA） was taken to detect the contents of plasma U Ⅱ and ADM. The changes of SaO2 and pulmonary arterial pressure （PAP） were also monitored. Results There were significant differences in PAP, SaO2 the contents of U Ⅱ and ADM of the COPD patients among the three groups （ P 〈0.01 ）. In COPD patients U Ⅱ content was negatively correlated with SaO2 （ P 〈 0. 05）, and positively correlated with PAP （ P 〈 0.05 ）. In patients with COPD U Ⅱ content was significantly increased, and higher at acute exacerbation stage than at remission stage, and the content of U Ⅱ and ADM were of a good positive correlation. Conclusion U Ⅱ as a vasoconstrictor factor may be involved in the formation of hypoxic pulmonary hypertension, and the increase of plasma U Ⅱ level followed by increased ADM in the body is one of the self - protective mechanisms.
出处
《中国全科医学》
CAS
CSCD
2008年第15期1329-1331,1334,共4页
Chinese General Practice
基金
国家自然科学基金资助项目(30370632)
