糖尿病腹膜透析患者微炎症及透析充分性与营养状态的关系

Relationship between Micro-inflammatory State,Dialysis Adequacy and Nutritional Status in Diabetic Nephropathy Patients Undergoing Peritineal Dialysis

目的探讨糖尿病肾病(DN)腹膜透析患者微炎症状态、透析充分性与营养状态的关系。方法测定45例DN及53例非糖尿病肾病(NDN)腹膜透析患者血清清蛋白(ALB)、血红蛋白(Hb)、C-反应蛋白(CRP)和IL-6水平,计算尿素清除率(Kt/V)。结果两组患者血清CRP、IL-6、ALB、Hb水平和Kt/V间差别有统计学意义(P<0.05)。DN患者的Kt/V与CRP、IL-6水平呈负相关,与ALB、Hb水平呈正相关(P<0.05);CRP水平与IL-6水平呈正相关,与ALB、Hb水平呈负相关(P<0.05);IL-6水平与ALB、Hb水平呈负相关(P<0.05)。结论DN腹膜透析患者比NDN患者微炎症更明显、透析充分性与营养状态更差,且这三者间存在密切关系。

Objective To explore the relationship between microinflammatory state, dialysis Adequacy and nutritional status in diabetic nephropathy （DN） patients undergoing peritoneal dialysis （PD）. Methods Serum CRP, ALB, Hb and IL -6 level were assayed, and Kt/V were calculated in 45 DN and 53 non -diabetic nephropathy （NDN） patients undergoing PD. Results As comparing with NDN patients, DN patients had higher levels of CRP, IL -6, lower Kt/V, Hb, ALB; there was negative correlation between Kt/V and CRP, IL- 6, positive between Kt/V and ALB, Hb, negative between CRP, IL- 6 and ALB, Hb, positive between CRP and IL- 6 in DN patients undergoing PD. Conclusion DN patients undergoing PD have a more obvious micro - inflammatory state, worse dialysis adequacy and poorer nutritional status than NDN patients. There were a close relationship between micro -inflammatory state, dialysis adequacy and nutritional status.