EB病毒BNLF-1基因的分子生物学研究进展

Progress in Molecular Biology of BNLF-1 Gene of EB Virus

位于EB病毒基因组U5 TR区内的BNLF 1基因 ,其转译产物为潜伏膜蛋白 (latentmembraneprotein1 ,LMP 1 ) ,由于LMP 1可以导致细胞转化并在EB病毒致癌过程中具有重要作用 ,因而成为近年来EB病毒分子生物学及相关肿瘤如人鼻咽癌、伯基特淋巴瘤、何杰金氏病等疾病病因发病学研究的热点 ,并取得了一批有重要意义的成果 ,文章从BNLF 1的基因结构及表达调控 ,LMP蛋白的结构及生化功能 ,LMP 1的生物学功能和LMP 1研究进行评述 .

The BNLF-1 gene located in U 5-TR region of Epstein-Barr virus genome encodes a latent membrane protein (LMP-1). As the protein can transform B cells and plays a key role in the carcinogenesis of EB virus, so it has become the “hot spot” of studying for the diseases relavance to EB virus, such as nasopharyngeal carcinoma, Burkitt's lymphoma, Hodgkins disease etc, and also the molecular biology of EB virus. A series of achievements have been achieved, the progress in following aspects are reviewed: 1 the structure and expressing regulation of BNLF-1 gene; 2 the structure and biochemical function of LMP-1 protein; 3 the biological function of LMP-1; 4 looking forward to the future.