颈动脉粥样硬化患者斑块稳定性与血脂水平的相关性研究

Correlation Study on the Plaque Stability and Blood Lipid Level inPatients with Carotid Atherosclerosis

目的观察不同类型颈动脉粥样硬化斑块患者血脂水平的变化及与斑块稳定性的相关性。方法70例伴有颈动脉粥样斑块的患者根据超声斑块形态分为易损斑块(vulnerable plaque,VP)组30例和稳定斑块(stable plaque,SP)组40例,另选50例无斑块者(NCP)为对照组,分别测定血脂水平的含量。结果与无斑块组比较,有斑块组血总胆固醇(TC)、低密度脂蛋白(LDL-C)较无斑块组显著增高,有显著差异(P<0.05);与稳定斑块组比较,易损斑块组血总胆固醇(TC)、低密度脂蛋白(LDL-C)明显增高,有显著差异(P<0.05)。结论血总胆固醇(TC)、低密度脂蛋白(LDL-C)在颈动脉粥样硬化患者中有明显变化,血总胆固醇(TC)、低密度脂蛋白(LDL-C)与患者斑块稳定性相关。

Objective To observe the blood lipid level changes in patients with different types of carotid atherosclerotic plaques and the correlation between blood lipid level and plaque stability. Methods According to the ultrasonographic appearance of the plaques, 70 cases with carotid atherosclerotic plaques were divided into 2 groups ： Group VP （vulnerable plaques ）（n = 30 ） , Group SP （stable plaque） （ n = 40）, in addition, 50 cases with no plaque were grouped to be the Control Group; the blood lipid levels of all the cases in 3 groups were detected. Results The levels of TC and LDL-C of Group VP and Group SP were of higher increase than those of Control Group while the level of TC and- LDL-C of Group VP were of higher increase than those of Group SP, the differences were significant （P 〈 0.05）. Conclusions TC and LDL-C have obvious changes in patients with carotid atherosclerosis, which axe correlated with the stability of the plaques.