伏立康唑与氟康唑对临床常见念珠菌体外抗菌活性比较

Comparison between Voriconazole and Fluconazole of Their Vitro Antibacterial Activity to Frequent Candida in Clinic

目的探讨伏立康唑和氟康唑对临床念珠菌的体外抗菌活性。方法采用Rosco纸片扩散法检测48株念珠菌对伏立康唑及氟康唑的药敏结果,并进行比较。结果白色念珠菌、光滑念珠菌、热带念珠菌、克柔念珠菌对伏立康唑的敏感率为100%;对氟康唑的敏感率分别为90%、37.5%、100%、0%。结论伏立康唑比氟康唑对念珠菌有更高的抗菌活性,在抗念珠菌感染时具有较好临床应用价值。

Objective To discuss the vitro antibacterial activity of Vorieonazole and Fiueonazole to frequent Candida in clinic. Methods Roseo paper disc diffusion was applied in detecting the susceptibility of 48 strains of Candida to Voriconazole and Fluconazole and the results were eompared. Results The sensitive rates of Candida albieans, Torulopsis glabrata, Candida tropiealis and Candida krusei to Vorieonazole were 100% while the rates to Flueonazole were 90%, 37.5%, 100% and 0% respectively. Conclusions Vorleonazole has a stronger antibaeterial aetivity to Candida than Flueonazole, and is worthy of application in elinie for Candida infection.