摘要
丝裂原活化蛋白激酶(MAPK)是体内四大信号转导系统之一,现已发现p38、ERK5/BMK1、ERK以及JNK/SAPK 4个亚族。它参与介导生长、发育、分裂、分化、死亡及细胞间功能同步等多种细胞过程,其中p38通路在炎症反应过程中起着非常重要的作用。在慢性支气管炎(chronic bronchitis)的进程中,p38通路通过对肺泡巨噬细胞(AM)等多种细胞的作用、对多种炎症因子生成的调控、对酶的诱导以及促进转录因子活化等机制来调节炎症过程的发生发展。该文就p38通路在慢支发病中的作用及研究进展作一综述。
Mitogen activated protein kinase （MAPK） is one of the four biggest signal transduction systems which contain four subtribes named p38, ERKS/BMK1, ERK and JNK/SAPK respectively. Previous studies have shown that MAPK pathway is involved in growth, cell differentiation, perishing, the synchronization of cell function and so on. p38MAPK,one of the members of MAPK family, plays an important role in the activation of in-flammation-related cells to release inflammation mediator,modulating enzyme production as well as transferring factors activity in the process of chronic bronchitis （CB）. This review focuses on multiple roles of p38MAPK in the pathogenesis and progression of CB.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第7期849-852,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30371766
30572355)
