儿童孤独症的遗传学研究进展

Progress in genetic research on childhood autism

儿童孤独症是一种起病于婴幼儿时期的严重发育障碍性疾病,临床主要表现为社会交往障碍、语言交流障碍和兴趣范围狭窄、重复或刻板运动的综合征,目前被认为是多因素、多基因遗传性疾病,但与其相关的基因尚未明确。文章从遗传学的几个方面进行论述,着重介绍与孤独症显著相关的候选基因。

Childhood autism is a serious neurodevelopmental disorder, It onsets in childhood and is characterized by impaired reciprocal social interaction, impaired language communication, and restricted, repetitive, or stereo-typed behavior. Current researches indicated that autism is a complex heritable disease with multi-genetic disorder and is impacted by multi-factors. However, the autism-specifically associated genes had not been found yet. This review covers the researches on genetics and focuses on introducinz candidate zenes nredominantly correlated with autism.