神经生长因子、血管内皮生长因子在腺样囊性癌侵袭转移中的作用

Functions of NGF and VEGF in the invasion and metastasis of adenoid cystic carcinoma

目的:观察神经生长因子(nerve growth factor,NGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)在腺样囊性癌(adenoid cystic carcinoma,ACC)组织中的表达,探讨NGF和VEGF在ACC侵袭转移机制中的作用。方法:采用免疫组化SP法对NGF、VEGF在63例ACC组织中的表达进行检测,并采用Cox比例风险回归模型对影响预后的多项临床因素进行分析。结果:NGF、VEGF在ACC组织中具有较高阳性表达,Cox模型提示NGF、VEGF、神经是否有侵袭、TNM分期、复发等是预后的危险因素,腺样-管状型的预后较实性型好。结论:ACC的预后与多因素相关,其中NGF、VEGF与ACC的侵袭转移有较大关系,可望作为判断预后的参考指标。

Objective：To study the functions of nerve growth factor （NGF） and vascular endothelial growth factor （VEGF） in the invasion and metastasis of adenoid cystic carcinoma （ACC）. Methods：63 ACC cases were chosen. NGF and VEGF were investigated by immunohistochemial SP analysis. Cox regression model was used for multivariate prognostic analysis with clinical data of these 63 ACC patients. Results：The expression of NGF and VEGF in ACC tissues varied in different pathological groups, clinical grades and conditions after operation, ect. Expressions of these two growth factors were related to the prognosis of patients. Conclusion： Prognosis of ACC might be related to various clinical factors. NGF and VFGF may be relevant to the characteristics of invasion and metastasis of ACC. Expression of NGF and VEGF could become predicators of prognosis of ACC patients.