13例妊娠期急性脂肪肝病例特点分析和总结

The analysis and summaries of 13 cases with acute fatty liver of pregnancy

目的探讨妊娠期急性脂肪肝病例特点进行分析和总结。提高对妊娠期急性脂肪肝的早诊早治能力,从而降低孕产妇及围产儿的死亡率。方法选择我院2002年以来救治的妊娠期急性脂肪肝13例,对其病例特点:包括孕妇年龄,发病症状,某些妊娠情况及肝、肾功能、凝血功能进行回顾性总结分析。结果发现69%的病例发生在妊娠35周,其中孕育男性胎儿者占80%。85%的病人有明显的消化系统症状,99%病人出现黄疸,肝肾功能检查可见:谷草转氨酶升高占100%,且均高于谷丙转氨酶,同时伴有尿酸血症。结论AFLP是一种妊娠期间特发的,以多脏器受损的一种产科危重病,多发生在妊娠35周左右。

Objective To explore the clinical features of acute fattyliver of pregnancy （AFLP） for early diagnosis and management timely and reduce the mortality of the mother and the fetus. Methods Retrospective analysis on I I patients admitted to our hospital from 2002 to 2007 with AFLP were performed. The following clinical Characteristics were explored：mother age, symptom, pregnancy circumstance, liver, kidney and dotting function damage, Results gestation 69% cases took place in 35 weeks. Among them the male embryo occupied 80%. 85% patients showed obvious digestive system symptom. 99% patients appeared jaundice. Liver and kidney function test showed： transaminase elevating occuping 100%, in complication with uric acid blood systerm.