我国葡萄膜炎研究进展及存在的问题

Advances in uveitis research in China

我国葡萄膜炎研究近年来取得很大进展。我国眼科工作者的研究表明,Th1细胞和Th17细胞均参与了葡萄膜炎发生。Fas/FasL表达不平衡所致的淋巴细胞对凋亡抵抗性增加,CD4+CD25highT细胞功能和数量降低,瘦素水平增高及一些因子的基因多态也参与了葡萄膜炎发生及复发。临床研究发现我国Vogt-小柳原田综合征和Fuchs综合征患者有独特的临床特征,激光前房闪辉一细胞计数仪和多焦ERG检测已大大推进了人们对葡萄膜炎病理生理改变的认识。但是我们应当看到,我国从事葡萄膜炎研究的医生还很少,诊断治疗水平尚需进一步提高。

Studies on uveitis have gained a great achievement during recent years in China. A number of studies have provided evidences to support the opinion that both Thl and Th17 cells are involved in the pathogenesis of uveitis. Increased resistance of lymphocytes to apoptosis due to disturbed expression and Fas / FasL, decreased frequencies and function of CD4＋CD25high T cells, increased leptin and polymorphisms of certain Cytokines are also involved in the development or recurrence of uveitis. Clinical studies have revealed distinctive features of Vogt-Koyanagi-Harada syndrome and Fuchs syndrome in Chinese patients. Studies using Laser flare-cell meter and multifocal electroretinography have greatly contributed to our understanding of the pathophysiological alterations of uveitis. A number of papers on uveitis have been published in the top journels of ophthalmology in the world. However, it is worthwhile to point that there are very few doctors engaged in uveitis study and that diagnosis and treatment of uveitis should be further improved in future in China.