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卵巢外腹膜浆液性乳头状癌临床特征、治疗及预后(附11例分析) 被引量:3

Clinical characteristics,treatment and prognosis of 11 cases with extraovarian peritoneal serous papillary carcinoma
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摘要 背景与目的:卵巢外腹膜浆液性乳头状癌(extraovarian peritoneal serous papillary carcinoma, EPSPC)是原发于腹膜间皮,有时可累及卵巢表面,呈多灶性发生的恶性肿瘤,发病率低,近年来逐渐引起人们的重视,目前暂无标准的治疗方案。本文分析11例EPSPC,初步探讨其临床特征、治疗及预后。方法:回顾性分析11例EPSPC临床特征,采用肿瘤细胞减灭术及术后辅助化疗进行综合治疗,最后采用RECIST评价近期疗效,进展时间(TTP)及总生存率评价远期疗效。结果:EPSPC患者临床表现均为腹痛,进行性加重腹胀、腹水,但仅有18.2%可体检查出腹部包块,腹水阳性率为100%。腹部B超、MRI扫描发现腹部包块的阳性率分别为45.5%、100%,血浆、腹水CA125升高>300U/ml(正常<35U/ml)的比率分别为72.7%(8/11)、81.8%(9/11)。EPSPC患者肿瘤细胞减灭术的成功率为45.5%。化疗完全缓解1例(11.1%,1/9),部分缓解3例(33.3%,3/9),稳定2例(22.2%,2/9),进展3例(33.3%,3/9),化疗有效率为4例(44.4%,4/9)。TTP为5~14个月,中位TTP为8.6个月,1、2、3年生存率分别为72.7%(8/11)、18.2%(2/11)和0%(0/11),中位生存期14.6个月。结论:EPSPC临床症状无特异,腹水癌细胞检查、腹部MRI以及血浆与腹水CA125的表达水平对诊断EPSPC最具有临床意义。EPSPC肿瘤细胞减灭术的成功率低,对化疗抗拒,预后极差。 Background and purpose: Extraovarian peritoneal serous papillary carcinoma(EPSPC) originats from peritoneum with rare incidence, sometimes may affect the surface of ovary and have multi-focal lesions, whose standard therapy have not been established. In this study, we preliminarily reviewed the clinical characteristics, treatment and prognosis of EPSPC in 11 cases. Methods: The clinical characteristics of 11 cases with EPSPC were first retrospectively analyzed. All the patients underwent cytoreduction surgery followed by chemotherapy. Finally, short-term and long-term efficacy, time to progression (TTP) and overall survival were evaluated by RECIST, respectively. Results: Abdominal pain, distention and ascites were the most common presenting symptoms, but tumors could be palpable in only 18.2% of the patients. The positive rate of ascites, abdomen B ultrasound,MRI scan and ascending CA125 level in the plasma and ascites was 100%,45.5%, 100%,72.7%,81.2%,respectively. The successful rate of cytoreduetion surgery was 45.5% for the EPSPC. After chemotherapy, the cases of complete remission, partial remission, stable disease and progression disease were 1(11.1%,1/9),3(33.3%,3/9),2(22.2%,2/9) and 3(33.3%,4/9), respectively. TTP was 5-14 months for all the patients and the median TTP was 8.6 months. The 1,2,3-year overall survival was 72.7%,18.2%,0%, respectively and the median overall survival was 14.6 months. Conclusions: Ascite, abdomen MRI scan and CA125 level are the most meaningful factor to diagnose EPSPC. EPSPC is a carcinoma of poor prognostic with non-specific clinical characteristics, low successful rate of cytoreduction surgery and is chemotherapy-resistent.
出处 《中国癌症杂志》 CAS CSCD 2008年第7期545-547,共3页 China Oncology
关键词 卵巢外腹膜浆液性乳头状癌 临床特征 治疗 预后 extraovarian peritoneal serous papillary carcinoma clinical characteristics treatment prognosis
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  • 1Swerdlow M. Mesolhelioma of the pelvie peritoneum resembling papillary cysladenocarcinoma of the ovary ease report [J]. Am J Obstet Gynecol, 1959, 77(1):197-200.
  • 2Bloss JD, Brady MF, Liao SY, et al. Extraovarian peritoneal serous papillary carcinoma: a phase 11 trial of cisplatin and eyclophosphamide with comparison to a cohort with papillary serous ovarian carcinoma-a Gynecologic Ontology Group Study [J]. Gynecol Oncol,2003,89( 1 ): 148-154.
  • 3Ayhan A, Taskiran C, Yigil-Celik N, et al.Long-lerm survival afler paclilaxel plus plalinum-based combinalion chemolherapy for exlraovarian periloneal serous papillary carcinoma: is it different from that for ovarian serous papillary cancer? [J].Int J Gynecol Cancer, 2006, 16(2):484-489.
  • 4Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluale the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Inslilute of the United Slates, Nalional Cancer Institule of Canada [J].J Natl Cancer Inst, 2000, 92(3):205-216.
  • 5Dalrymple JC, Bannatyne P. Russell P, et al.Extraovarian periloneal serous papillary carcinoma. A clinicopalhologic sludy of 31 cases [J] . Cancer, 1989, 64(1):110-115.
  • 6Fromm GL, Gershenson DM, Silva EG. Papillary serous eareinoma of the peritoneum [J] . Obstet Gynecol, 1990, 75(1):89-95.
  • 7张燮良,刘素香.腹膜癌[J].中国肿瘤临床,1998,25(5):383-385. 被引量:15
  • 8Bloss JD, Liao SY, Buller RE, et al.Extraovarian peritoneal serous papillary carcinoma: a case-control retrospective comparison to papillary artenocarcinoma of the ovary[J]. Gynecol Oncol, 1993, 50(3):347-351.
  • 9Zhou J, Iwasa Y, Konishi I, et al.Papillary serons carcinoma of the peritoneum in women. A clinicopathologic and immunohistochemical study[J] . Cancer, 1995, 76(3):429-436.
  • 10彭燕蓁,沈铿,吴鸣,黄惠芳,潘凌亚,杨佳欣,郎景和.腹膜浆液性乳头状腺癌的临床分析[J].中华妇产科杂志,2005,40(4):243-245. 被引量:8

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