兔血液凝血功能诊断的逐步判别与分析

Application of stepwise discriminatory analysis to blood coagulation function diagnosis

目的测定兔胸部不同程度撞击伤后凝血指标的变化,并对传统的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)和纤维蛋白原(FIB)含量等指标进行筛选。方法用相关分析做数据预处理剔除指标,再用逐步判别分析(stepwise discriminant analysis,SDA)选入指标,并用多元线性判别分析诊断,最后随机抽样比较剔除指标前后的诊断效果。结果用逐步判别分析法选入4项指标,判别正确率达87.60%;剔除指标FIB后,判别正确率达96.12%;1000次抽样诊断检验,4项指标和3项指标的平均诊断正确率分别为83.07%和85.16%。结论逐步判别分析可有效判别兔血液出、凝血功能状况,剔除指标FIB后诊断正确率略有提高。

Objective To determine the changes of coagulation indexes of rabbits struck at different levels and sieve the traditional coagulation indexes, such as activated partial thromboplastin time （APTT） , prothrombin time （PT） , thrombin time （TT） and fibrinogen （FIB）. Methods We used correlation analysis to precondition the data to reject indexes, and used stepwise discriminatory analysis to choose indexes and made the diagnosis bv muhiple linear discrimination analysis. Then, by random sampling we compared the correct diagnostic rate by 4 indexes with that by 3 indexes. Results The correct discrimination rate of blood coagulation function diagnosis in rabbits was up to 87.60% by the four indexes and 96.12% with the three indexes （ APTT, PT and TT）. rFhe average correct discrimination rate of blood coagulation function diagnosis in 1 000-time random sampling was up to 83.07% by the four indexes and 85.16% by the three indexes. Conclusion Stepwise discriminatory analysis can be used to discriminate hemon＇hage from thromboxane. The correct diagnostic rate gets higher when FIB was rejected.