胃癌组织中Survivin,Bcl-2,Bax蛋白的表达及意义

Expression of Survivin,Bcl-2,Bax in gastric carcinoma and its clinical significance

目的：探讨Survivin，Bcl-2，Bax蛋白在胃癌中表达与临床病理的关系。方法：应用免疫组化方法观察Survivin，Bcl-2，Bax蛋白在胃癌（年龄30～82岁，男68例，女32例）中的表达。结果：Survivin表达阳性率为47.0％；Bcl-2表达阳性率为57．0％；Bax表达阳性率为33.0％。分化较好组的Survivin蛋白表达阳性率低于分化较差组，有显著性差异（30.0％vs54.3％，P〈0.05），分化较差组的Bcl-2阳性表达率（64．3％）明显高于分化较好组（40.0％），有显著性差异（P〈0．05），分化较好组中Bax蛋白阳性率高于分化较差组，有显著性差异（56．1％vs22．9％，P〈0．05）。Survivin，Bcl-2表达率在淋巴结转移组高于无转移组，Bax表达率正相反。结论：Survivin，Bcl-2和Bax在胃癌的发生、发展中起着不同程度的作用，它们的检测对胃癌恶性程度的判定、预后分析和进一步治疗提供有效的依据。

AIM： To investigate the relationship between the expression of Survivin, Bcl-2, Bax and the clinicopathologic parameters in gastric carcinoma. METHODS： Immunohistochemical method was used to detect the expression of Survivin, Bcl-2 and Bax in 100 cases of gastric carcinoma（ 68 males, 32 females ）aging from 30 to 82. RESULTS： Survivin positive expression rate was 47.0%. Bcl-2 positive expression rate was 57.0%. Bax positive expression rate was 33.0%. In the well-differentiation group, Survivin positive expression rate was lower than that in the poordifferentiation group（30.0% vs 54.3%,P 〈 0.05 ）. In the poordifferentiation group, Bcl-2 positive expression rate （64.3%） was higher than that in the well-differentiation group（40.0% ） （ P 〈 0.05）. In the well-differentiation group, Bax positive expression rate was higher than that in the poor-differentiation group（56.1% vs 22.9% , P 〈 0.05 ）. The expression rates of Survivin, Bcl-2 were higher in the lymphnode metastasis group than in non-metastasis group. While Bax expression rate was lower in metastasis group than in non-metastasis group. CONCLUSION： Survivin, Bcl-2 and Bax play different roles in gastric carcinoma occurrence and development. Their detection could afford effective basis for assessment, prognosis analysis, and further treatment of gastric carcinoma.