液基薄层细胞联合阴道镜筛查宫颈病变的临床研究

Clinical study of thinprep cytologic test combined with biopsy under colposcope in diagnosis of cervical squamous intraepithelial lesions

目的:研究液基薄层细胞学(TCT)联合阴道镜对宫颈病变筛查的临床应用价值.方法:选择妇科门诊临床可疑患者476例进行宫颈病变筛查,其中255例患者行TCT联合阴道镜检查并镜下指导活检(实验组),221例直接阴道镜检查并镜下指导活检(对照组),最终均以组织学诊断为金标准,比较两组组织学诊断阳性符合率.结果:实验组组织学诊断阳性符合率为74.12%(189/255),对照组为52.49%(116/221),两组诊断符合率比较差异有统计学意义(P<0.01).结论:TCT联合阴道镜活检可提高宫颈上皮内瘤变阳性诊断率,是筛查和诊断宫颈病变的可靠手段.

AIM： To investigate the diagnostic value of thinprep cytologic test （TCT） combined with biopsy under colposcope for cervical squamous intraepithelial lesions （CIN）. METHODS： The suspected patients （ n = 476） were assigned to TCT combined with biopsy under colposcope （TCT group, n = 255 ） or biopsy under colposcope randomly （control group, n = 221 ）. Pathologic examination of biopsy samples was used as gold standard. RESULTS： The coincidence on diagnosis of cervical lesions between TCT and pathologic examination of biopsy samples was 74. 12% （ 189/255 ）, and the coincidence in control group was 52. 49% （116/221）. The difference between the two groups was significant statistically （ X^2 = 363.75, P 〈 0.01 ）. CONCLUSION： TCT combined with biopsy under colposcope can increase the diagnostic accuracy of cervical intraepithelial neoplasia, and become a reliable method to screen and diagnose the precancerous lesion of cervix.