对立违抗性障碍儿童的脑功能磁共振成像特点

Features of functional MRI in children with oppositional defiant disorder

目的:研究对立违抗性障碍儿童冲动控制作业下的脑功能磁共振成像特点,以探讨冲动控制的脑结构。方法:对立违抗性障碍儿童10例,正常对照组10例,按年龄、性别配对。刺激任务采用GOSTOP软件,运用刺激-休息-刺激的模式。数据分析采用国际通用的SPM软件,分别将两组数据标准化、合并和平均,对两组平均后的脑激活图像的激活区域及分布进行比较。结果:患儿组激活范围广泛而且弥散。对照组主要是额极(额下回、额中回和额叶眶部)和颞极(颞下回和颞中回)被激活。结论:脑额极可能是参与冲动控制的重要脑神经结构,对立违抗性障碍儿童额极功能相对低下。

Objective To determine the charactericstics of functional magnetic resonance imaging in brain of children with oppositional defiant disorder （ODD）when performing an impulsive task and to explore the brain structure of impulsivity. Methods Ten ODD children and 10 age and sexmatched control children were recruited. The stimulus task with GOSTOP impulsivity paradigm software was used as the mode of stimulus-rest-stimulus. The data of 2 groups were normalized, merged, and averaged, and then the activation regions were compared by SPM software. Results More scattered cortex and subcortex regions were activated in the ODD group than in the control group during the performance of an impulsive task. The activated cortex in the control group focused on the frontal pole （including inferior frontal gyrus, middle frontal gyrus and orbital-frontal gyrus ） and temporal pole （ including inferior temporal gyrus and middle temporal gyrus ）. Conclusion Frontal pole may be an important region related to multiplicity impulsivity, and shows hypofunction in ODD children.