氯氮平与阿立哌唑治疗精神分裂症临床疗效的对照研究

Controlled study of clozapine and aripiprazole in the treatment of schizophrenia

目的评价阿立哌唑与氯氮平治疗精神分裂症的疗效与不良反应。方法将78例精神分裂症患者随机分为2组,分别予以氯氮平及阿立哌唑治疗,疗程8周。采用潘氏量表、副反应量表评定临床疗效和不良反应。结果两组临床疗效比较无显著性差异(P>0.05)。两组PANSS评分分析,治疗前后比较有显著性差异(P<0.05),两组间比较无显著性差异(P>0.05)。结论阿立哌唑与氯氮平治疗精神分裂症均有效,前者不良反应少,安全性高。

Objective To compare the curative effects and side effects of aripiprazole and clozapine on schizophrenia.Methods 78 schizophrenics were randomly divided into aripiprazole and clozapine groups.The therapeutic effects and side effects were assessed with the Positive And Negative Symptom Scale（PANSS） and Treatment Emergent Symptom Scale（TESS） before and at the end of 2nd,4th and 8th week of treatment respectively.Results There was no significant difference in curative effect and PANSS between two groups,but there were significant differences before and after inpatient treatment.Aripiprazole group had fewer side effect than clozapine group.Conclusion Aripiprazole and clozapine are effective in the treatment of schizophrenia.Aripiprazole has fewer side effects.