Livin和Smac在T细胞淋巴瘤中的表达及意义

Expression and clinical significance of Smac and Livin in T cell non-Hodgkin's lymphomas

目的:探讨凋亡抑制因子Livin和凋亡促进因子Smac在T细胞非霍奇金淋巴瘤(T-NHL)中的表达与临床特征及预后的关系。方法:采用免疫组织化学SP法检测42例T-NHL中的Livin、Smac蛋白表达情况,并对其中25例具有完整临床随访资料进行临床特征及生存分析研究。结果:Livin、Smac蛋白在42例T-NHL中阳性表达率分别为57.1%和50.0%,两者表达具有相关性。Livin蛋白表达与B症状、国际预后指数高危及生存期短有关;Smac蛋白表达与无B症状、Ann-Arbor分期早和国际预后指数低危有关。结论:Livin蛋白表达与T-NHL患者不良临床特征及预后相关,而Smac表达与临床特征良好相关。

Objective：To investigate the expression and clinical significance of Smae and Livin in T cell non-Hodgkin＇s lymphomas（T-NHL）. Methods：Expression of Smae and Livin were detected by immunohistoehemieal staining （SP） assay in 42 T-NHL cases. Relation between Smae 、Livin and clinical staging, effect and prognosis of 25 T-NHL cases were analyzed. Results-The expression rates of Livin and Smae proteins in T-NHL were 57.1% and 50. 0%. There was significant correlation between them; The positive expression rate of Livin has relation with B symptom ,high risk IPI and shorter survival time. Whereas the positive rate of Smae was significantly higher in the patients with no B symptom,early clinical staging and low risk IPI. Conclusion： In T-NHL, the expression of Livin protein is related with poor prognosis and adverse clinical features, While the expression of Smae protein was related with good clinical features.