幽门螺杆菌感染与胃粘膜萎缩肠化生及不典型增生的关系

Relationship between HP Infection and Gastric Mucosa Atrophy, Intestinal Metaplasia, Dysplasia

对以上消化道症状而就诊的３２１例慢性胃炎患者行胃镜及幽门螺杆菌（ＨＰ）检测和胃粘膜病理学检查，结果显示慢性萎缩性胃炎的ＨＰ检出率为７６．１％，显著高于慢性浅表性胃炎的检出率５６．３％（Ｐ＜０．０１），ＨＰ感染患者胃粘膜萎缩和肠化生的发生率分别为２６．３％和２９．９％，显著高于无ＨＰ感染者胃粘膜萎缩和肠化生的发生率１２．６％及１９．７％（Ｐ＜０．０１和Ｐ＜０．０５）．且ＨＰ感染与胃粘膜萎缩程度有显著关系，而与肠化生程度和不典型增生无显著关系（Ｐ＞０．０５）．提示ＨＰ感染可以使胃粘膜萎缩和肠化生的发病率升高，并认为ＨＰ感染可能为胃癌发生的危险因素之一．

Three hundred and twenty one cases of chronic gastritis with upper digestive tract symptoms were detected by gastroscopy, pathology and HP determination.The detection ratio of HP in chronic atrophic was significantly higher than that in chronic superficial gastritis (70.1% and 56.3%, P <0.01),the ratio of atrophy and intestinal metaplasia in gastric mucosa with HP infection was significantly higher than that in gastric mucosa without HP (26.3%,29.9% and 12.6%,19.7%; P <0.01 and P <0.05),the degree of atrophic had close relationship with HP infection, but there was no significant difference between HP infection and intestinal metaplasia dysplasia ( P >0.05). The results suggested that HP infection increased the risk of developing gastric mucosa atrophy and intestinal metaplasia and that HP infection was one of the co carcinogenic factors of gastric cancer.