外周动静脉同步自动换血治疗新生儿高胆红素血症26例效果观察

Observation on the effect of synchronous exchange transfusion of peripheral artery and vein in the treatment of 26 neonates with hyperbilirubinemia

目的:探讨外周动静脉同步自动换血治疗新生儿高胆红素血症的疗效。方法:监测自动换血的26例新生儿高胆红素血症患儿换血前后胆红素、血常规、电解质、血糖、pH值及凝血功能指标的变化,并监测患儿换血过程中生命体征及血氧饱和度的变化。结果:外周动静脉自动换血前后血清总胆红素分别为530.7±85.6μmol/L、230.8±93.1μmol/L,换血前后间接胆红素分别为465.3±55.8μmol/L、220.6±65.2μmol/L,换血后总胆红素、间接胆红素下降率分别为56.5%、52.6%。换血前后胆红素值比较差异有极显著性(P<0.01)。结论:外周动静脉同步自动换血法是治疗新生儿高胆红素血症简便易行、节省人力、安全有效的方法。

Objective ： To study the effect of synchronous exchange transfusion of peripheral artery and vein in neonates with hyperbilirubinemia. Methods： In 26 neonates who were performed synchronous exchange transfusion, bilirubin, results of blood routine test, electrolyte, blood glucose, pH and coagulation function were detected before and after exchange transfusion. Changes of vital signs and blood oxygen saturation level were also monitored. Results： Before and after synchronous exchange transfusion of peripheral artery and vein, concentration of total bilirubin and indirect bilirubin were 530. 7 ±85.6μmoL/L, 230.8 ±93.1 μmoL/L and 465.3 ±55.81μmoL/L, 220.6 ±65.2μmoL/L respectively. Total bilirubin and indirect bilirubin reduced 56.5% and 52.6% respectively after exchange transfusion. There were significant differences in the comparison before and after exchange transfusion （ P 〈 0. 01 ）. Conclusion ： Synchronous exchange transfusion is one of ideal methods for treating neonatal hyperbilirubinemia. The technique is simple, economical and safe.