摘要
目的对比研究长期摄入高剂量不同富硒植物对大鼠体内硒累积分布的影响。方法采用N-甲基-N’-硝基-N-亚硝基胍(MNNG)诱发大鼠胃癌模型,连续灌以硒高剂量四种不同富硒植物17周,测定大鼠硒累积以及参与硒蛋白合成组织的含硒量。结果摄入富硒青花菜、富硒红羽、富硒绿羽的大鼠肝和肾硒水平显著高于摄入富硒大蒜的,摄入富硒大蒜的大鼠红血球和脾脏硒水平显著高于摄入富硒青花菜、富硒红羽和富硒绿羽的。结论初步认为长期摄入高剂量植物硒后,动物组织硒的累积和分布取决于摄入的硒种类;与其它源硒相比,长期摄入高剂量富硒大蒜后,动物肝组织的低硒累积可以作为富硒大蒜高安全性的重要依据之一。
Objective To investigate the accumulation and distribution of blood and tissue Se in rats with long-term and high-dose of Se supplementation by four Se-enriched plants （Se-enriched garlic, Se-enriched broccoli, Se-enriched green kale and Se-enriched red kale） in the N-methyl-N＇-nitro-N-nitrosoguanidine （MNNG）-induced stomach cancer model. Methods Ninety rats were fed by basal diet for a week, divided equally into the control, MNNG and seven Se supplementation groups. Rats were daily given 15mg/kg bw of MNNG for ten days except those in the control group, and rats in five Se-enriched plant treatment groups were daily given 150 or 300μgSe/kg bw of the plant suspension by gavage for 17 weeks. Rats were sacrificed at the end of 18th week, the Se contents of blood, red blood cell, plasma, liver, kidney, spleen, heart, brain and testicle were determined. Results The Se contents of liver and kidney in rats supplemented by Se-enriched garlic were significantly lower than those in rats supplemented by Se-enriched broccoli and two Se-enriched kales, and the Se contents of red blood cell and spleen higher than those in rats supplemented by Se-enriched broccoli and two Se-enriched kales. Conclusion The data primarily shows that the differences of the accumulation and distribution of blood and tissue Se in rats are related to the supplemented plant Se components, and that lower Se accumulation of the liver and kidney in rats supplemented by Se-enriched garlic than by other plants may be one of Se safety indices of Se-enriched garlic.
出处
《卫生研究》
CAS
CSCD
北大核心
2008年第4期435-437,共3页
Journal of Hygiene Research
基金
国家自然科学基金资助项目(No30170800)
