期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

羟考酮的镇痛及依赖的实验研究进展 被引量：2

原文传递
导出
摘要 羟考酮（oxycodone）又称14-羟基二氢可待因酮、羟可酮、氧可酮。其化学式为4，5-还氧基-14-羟基-3-甲氧基吗啡烷-6-酮。是阿片类生物碱蒂巴因（thebaine）的衍生物。羟考酮在临床应用有80多年的历史。首先在美国羟考酮与非阿片类药物的复方制剂口服用于治疗中、重度癌性和非癌性疼痛。大量临床试验证明，单一制剂羟考酮，可控制非阿片类药物与羟考酮、或吗啡的复方制剂无法缓解的中、重度癌性和非癌性疼痛。目前在我国已有羟考酮的产品进入市场。本文将系统的综述羟考酮的镇痛及其依赖的实验研究进展。
作者 刘艳丽 郝丽莉 李笑然 宫泽辉
机构地区 苏州大学药学院 军事医学科学院毒物药物研究所
出处 《中国药物滥用防治杂志》 CAS 2008年第4期221-222,共2页 Chinese Journal of Drug Abuse Prevention and Treatment
关键词 羟考酮 实验研究 镇痛 非癌性疼痛 非阿片类药物 二氢可待因酮 阿片类生物碱 复方制剂
分类号 R96 [医药卫生—药理学] R749.61 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献14

  • 1Mather L E.:analgesic drug.In:Anaesthesia.Eds.:w.S.Nimmo & G. Smith.Blackwell Scientific Publications.Oxford, London,Edinburgh,Boston,Melbourne. 1989,pp.73-104
  • 2Leow K P and Smith M T. The antinociccptive potencies of oxycodone, noroxycodone and morphine after intracervbroventricular administration to rats. Life Sci, 1994, 54: 1229-36
  • 3Ross F B, Smith M T. The intrinsic antinociceptive effects of oxycodone appear to be k -opioid receptor mediated. Pain, 1997, 73:151-7
  • 4刘艳丽,颜玲娣,吴春福,宫泽辉.不同阿片受体在羟考酮引起小鼠高活动性和镇痛过程中的作用[J].中国药理学通报,2007,23(11):1484-1489. 被引量：10
  • 5Carsten K. Nielsen, Fraser B. Ross, Shahrdad Lotiipour, Kamal S. Saini, Stephen R. Edwards, Maree T. Smith.Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain.Pain,2007, 132: 289-300
  • 6Beardsley P M, Aceto M D, Cook C D, et al. Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys. Exp Clin Psychopharmacol. 2004, 12:163-72
  • 7Chen Z R, Irvine R J, Somogyi A, et al. Mu receptor binding of some commonly used opioids and their metabolites. Life Sci 1991, 48:2165-71
  • 8ThompsonCM, Wojno H, Greiner E,MayEL, Rice KC, Selley DE.Activation of G-proteins by morphine and codeine congeners:insight to the relevance of O- and N-demethylated metabolites at 1- and d-opioid receptors. J Pharmacol Exp Ther 2004;308:547-54
  • 9Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shell DD. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther 2006;79:461-79
  • 10刘艳丽,吴春福,宫泽辉.L-四氢巴马汀抑制羟考酮依赖的小鼠和大鼠戒断症状的实验研究[J].中国药物滥用防治杂志,2005,11(3):150-152. 被引量：12

二级参考文献33

  • 1王卫平,谢潞,郑继旺,蔡志基.大白鼠固定比率连续自身给药实验动物模型的建立[J].中国药物依赖性通报,1994,3(4):214-217. 被引量：12
  • 2陈晓岚,刘景根,池志强.阿片成瘾的细胞分子机制[J].中国药理学通报,2005,21(8):901-904. 被引量：14
  • 3金国章 汪晓立 等.新化学类型多巴胺受体阻滞剂四氢原小檗碱同类物[J].中国科学：B辑,1985,(10):925-925.
  • 4Cannon CM,Bseikri MR.Is dopamine required for natural reward[J]? Physiol Behav,2004,81(5):741-748.
  • 5Li Z,Wu CF,Pei G,Guo YY,Li X.Antagonistic effect of pseudoginsenoside-F11 on the behavioral actions of morphine in mice[J].Pharmacol Biochem Behav,2000,66(3):595-601.
  • 6Johnson DW,Glick SD.Dopamine release and metabolism in nucleus accumbens and striatum of morphine-tolerant and nontolerant rats[J].Pharmacol Biochem Behav,1993,46(2):341-347.
  • 7WuCF YouS LiuW XuYM LiFL YaoXS.Effects of bilobalide and extract of Ginkgo biloba L on contents of dopamine and its metabolites in striatum and limbic system[J].中草药,1995,26(5):253-254.
  • 8Nestler EJ.Historical review:Molecular and cellular mechanisms of opiate and cocaine addiction[J].Trends Pharmacol Sci,2004,25(4):210-218.
  • 9Self DW,Nestler EJ.Molecular mechanisms of drug reinforcement and addiction[J].Annu Rev Neurosci,1995,18:463-495.
  • 10Kalso E,Vainio A.Morphine and oxycodone hydrochloride in the management of cancer pain[J].Clin Pharmacol Ther,1990,47(5):639-646.

共引文献34

同被引文献30

  • 1Basil Al-Awabdy,C Mel Wilcox.Use of anesthesia on the rise in gastrointestinal endoscopy[J].World Journal of Gastrointestinal Endoscopy,2013,5(1):1-5. 被引量：5
  • 2王晓,郑立运,赵志鸿,张艳,周玉冰,江金花,王庆端.盐酸千金藤碱抗乙型肝炎病毒的体外实验研究[J].时珍国医国药,2010,21(12):3109-3111. 被引量：3
  • 3吴立军.天然药物化学[M].北京:人民卫生出版社,2012:471.
  • 4Pinelli A, Trivulzio S, Brenna S, et al. Pretreatment with tetrandrine has protective effects against isoproterenol-in- duced myocardial infarction in rabbits [J]. In Vivo, 2010, 24 (3) : 265-270.
  • 5Bae DS, Kim YH,Pan CH,et al. Protopine reduces the in- flammatory activity of lipopolysaccharide-stimulatedmurine macrophages [J]. BMB Rep,2012, 45(2):108-113.
  • 6Wangchuk P, Keller PA, Pyne SG,et al. A new protoberber- ine alkaloid from Meconopsis simplicifolia (D. Don) Walp- ers with potent antimalarial activity against a multidrug re- sistant Plasmodium falciparum strain[J]. J Ethnopharma- eol,2013,150(3) :953-959.
  • 7Margiotta A, Gray BH. Assessment of recurrent mesenterie isehemia after stenting with a pressure wire[J]. Vase Med, 2014, 19(2): 137-141.
  • 8Chen CH, Liao CH, Chang YL,etal. Protopine, a novel mi- crotubule-stabilizing agent, causes mitotic arrest and apoptot- ic cell death in human hormone-refractory prostate cancer cell lines[J]. Cancer Lett,2012, 315(1) :1-11.
  • 9吕蒙恩,肖青,王琳,苏凤菊,陈治中,石亮,胡丽华.汉防己甲素抑制PANC-1细胞增殖作用的机制探讨[J].临床血液学杂志（输血与检验）,2010,23(3):327-332. 被引量：1
  • 10陈鹏,弥曼.左旋四氢巴马汀对局灶性脑缺血再灌注大鼠脑内核转录因子-κB细胞黏附分子-1表达的影响[J].山西医药杂志（上半月）,2010,39(8):694-697. 被引量：3

引证文献2

二级引证文献13

中国药物滥用防治杂志
2008年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部