手性N-苄氧甲酰基氨基酸芳基酯的合成及其生物活性

Synthesis of Chiral Aryl Esters of N-Benzyloxy-formoyl-amino Acid and Their Biological Activity

在三氯氧磷和吡啶的作用下，N-苄氧甲酰氨基酸和酚发生缩合反应生成了一系列Ⅳ．苄氧甲酰氨基酸芳基酯（5和6），产率60．7％-76．9％，其结构经。^HNMR，^13CNMR和IR表征。初步的生物活性结果表明，5和6的杀虫活性较低。

A series of aryl esters of N-benzyloxy-formoyl-amino acids （5 and 6） were synthesized in yields of 60.7% -76.9% by condensation reactions of N-benzyloxy-formoyl-amino acids with substituted phenols in the presence of phosphorus oxychloride and pyridine. The structures were characterized by ^1H NMR, ^13C NMR and IR. Biological activity experimental resullts showed that insecticidal activities of 5 and 6 were very low.