5-(吲哚基-3-次甲基)(硫代)巴比妥酸的合成

Synthesis of 5-(Indolyl-3-methylidyne)(Thio) Barbituric Acid

以冰乙酸为催化剂,吲哚-3-甲醛与巴比妥酸或硫代巴比妥酸在无水乙醇中进行Knoevenagel缩合,合成了5-(吲哚基-3-次甲基)巴比妥酸或5-(吲哚基-3-次甲基)(硫代)巴比妥酸,其结构经1H NMR和IR表征。

5- （Indolyl-3-methylidyne） barbituric acid or 5- （ indolyl-3-methylidyne ） （ thio ） barbituric acid was synthesized by Knoevenagel condensation of barbituric acid or thiobarbiturlc acid with indole-3-carboxaldehyde in absolute ethyl alcohol using glacial acetic acid as a catalyst. The structures were confirmed by ^1H NMR and IR.