紫杉醇联合顺铂同期放疗综合治疗局部中晚期鼻咽癌

CLINICAL OBSERVATION OF RADIOTHERAPY CONCURRENTLY COMBINED WITH TP CHEMOTHERAPY FOR STAGEⅢ,ⅣA NASOPHARYNGEAL CARCINOMA

目的评价紫杉醇联合顺铂同期放疗综合治疗局部中晚期鼻咽癌的疗效及不良反应。方法38例局部中晚期鼻咽癌患者行紫杉醇联合顺铂方案化疗,4周为1周期,共行2个周期。放疗在化疗第1个周期同期进行。结果38例入组患者同期放化疗毒性可耐受。总有效率(CR+PR)100%。三年随访,中位生存时间为33.9个月,中位局部无进展生存时间为32.5个月,1、2、3年局部无进展生存率分别为94.7%、86.8%、76.3%,1、2、3年总生存率分别为97.4%、84.2%、76.3%。结论紫杉醇联合顺铂同期放疗综合治疗局部中晚期鼻咽癌的疗效较好,毒副反应患者能耐受,安全可行。

Objective To evaluate the efficacy and adverse effects of radiotherapyconcurrently combined with TP chemotherapy for stage Ⅲ ,ⅣA nasopharyngeal carcinoma （NPC）. Methods 38 patients with NPC received 2 cycles TP（Taxol, DDP） chemotherapy and 4 weeks was a cycle. The conventional radiotherapy was given after the first cycle chemotherapy. Results Toxicity was durable in 38 patients received radiotherapy concurrently combined with chemotherapy. The total response was 100%. Median time was 33.9 months, and the 1 -, 2 -, 3 - year survival rates was97.4% ,84.2% ,76.3% . The 1 - , 2 - , 3 - year local progression - freely survival rates were94. 7% ,86.8% ,76.3% respectively, with the median local progression -freely survival time of 32.5 months respectively during three year follow - up visit. Conclusion The radiotherapy concurrently combined with TP chemotherapy for patients with stage Ⅲ ,ⅣA nasopharyngeal carcinoma could be more effectively, and the patients could tolerate the side effects, this therapy method was secure and receivable.