围生儿唇腭裂的发生情况及危险因素分析

Investigation of cleft lip palate in perinatal infants and analysis of the risk factors

目的探讨围生儿唇腭裂的发生情况及危险因素分析。方法对2000～2005年在济南市妇幼保健医院出生的所有围生儿,计算围生儿唇腭裂的发生率,采用1∶1配比的病例对照研究方法,以统一的调查表对围生儿唇腭裂的的父母和对照组的父母进行调查,应用SPSS软件对所有的调查因素进行单因素及多因素非条件Logistic回归分析。结果该市围生儿唇腭裂的发病率为1.93‰,围生儿唇腭裂的发生在不同孕母年龄和不同性别的婴儿之间差异无显著性,但在不同孕母年龄和城乡之间差异有显著性,农村明显高于城市。多因素非条件Logistic回归分析结果显示:接触宠物、妊娠剧吐、父亲职业接触不良物质、有异常生育史、家庭成员有异常生育史为发生围生儿唇腭裂的差异有显著性的危险因素。结论围生儿唇腭裂的发生是遗传与环境共同作用的结果。

[Objective] To investigate epidemic characteristics of cleft lip palate in perinatal infants and analysis the possible risk factors. [Methods] To monitor perinates infants from 2001 to 2005 borned in Jinan maternity and child care hospital, we get the incidence of cleft lip and palate. Through 1：1 matched case-control study, we interviewed the parent of cases and controls of cleft lip and palate with a unified questionnaire to screen its risk factors. Statistics methods included chi-squared test, univalent and multiple unconditional Logistic regression analysis on SPSS. [Results] The incidence of cleft lip and palate was 1.93%o. Sex of infant is no significance to the morbidity of cleft lip and palate. The older of mother, the higher of morbidity. The morbidity of cleft lip and palate in village is higher than in city. Multivariate unconditional Logistic regression showed that contact house pet, hyperemesis gravi- darum, fathers＇s exposure to danger material, abnormal childbearing history and abnormal childbearing history of family member is risk factors with statistical significance. [Conclusionl Generations and environmental factors are play in common in the formation of CLP.