白介素-8基因多态性与肿瘤易感性关系的研究进展

Progress in research on relationship between genetic polymorphisms of IL-8 and susceptibility of cancers

目的：综述白介素-8基因多态性与肿瘤易感性的关系。方法：以“IL-8、基因多态性、肿瘤”为关键词，运用PubMed central、Springer、CBM、清华同方全文数据库和重庆维普检索系统，检索2004～2007年发表的文献，共收集文献241篇，仔细阅读全文，排除重复或类似的研究及与基因多态性无关的文献，选取具有代表性的文献32篇，最终纳入分析24篇。结果：IL-8—251位点多态性与乳腺癌、结直肠癌、前列腺癌、口腔鳞状细胞癌和卡波肉瘤的发病有关，与肺癌、食管鳞状细胞癌、膀胱癌和恶性黑色素瘤的发病无关，与胃癌发病的关系尚待进一步研究。结论：IL-8基因-251位点单核苷酸多态性的发现，使IL-8与肿瘤关系的研究进入了基因调控水平，深入研究两者间的关系，可对研究肿瘤的发生发展和预防提供帮助。

OBJECTIVE： To review the literature of the relationship between genetic polymorphisms of IL-8 and susceptibility of cancers. METHODS： PubMed central, Springer, CNKI and CBM retrieval systems were used to search the papers ac cording to the keywords of interleukin 8, single nucleotide poly morphism and neoplasms, from 2004 to 2007, and 241 articles were got together. After excluding the articles that had no relation of tumor study, 24 articles were analysed. RESULTS： IL-8 -251A/T SNP was associated with breast cancer, colorectal cancer, prostate cancer, oral squamous cell carcinoma and Kaposi sarcoma, and increased the risk of lung cancer, esophageal squamous cell carcinoma, carcinoma of bladder and chromoma. The relationship between IL-8 -251A/T SNP and gastric cancer need be researched in the future. CONCLUSION： Analysis of the relationship between IL-8 gene polymorphisms and human tumors deeply will be helpful to understand the mechanism of tumor oc curren and improve the tumor precaution.