食管鳞癌组织IGF-Ⅰ和IGF-IR的表达及其相关性研究

Expression and correlation of IGF-Ⅰ and IGF-IR in esophageal squamous cell carcinoma

目的:研究食管鳞癌组织中胰岛素样生长因子-Ⅰ(insulin-like growth factor,IGF-Ⅰ)及其受体(insulin-like growth factor receptor,IGF-IR)的表达及相关关系。方法:应用免疫组化SP法检测49例食管鳞癌组织、19例不典型增生组织及32例正常黏膜上皮组织中IGF-Ⅰ和IGF-IR的蛋白表达。结果:在正常食管黏膜、不典型增生组织和食管鳞癌组织中IGF-Ⅰ和IGF-IR的表达分别为34.4%(11/32)、52.6%(10/19)、69.4%(34/49)和31.3%(10/32)、52.6%(11/19)、71.4%(35/49),正常食管黏膜与食管鳞癌组织比较差异均有统计学意义,P<0.05。IGF-Ⅰ和IGF-IR的蛋白表达与淋巴道转移、浸润深度及分化程度有关。IGF-Ⅰ的表达和IGF-IR的表达之间呈正相关。结论:联合检测IGF-Ⅰ和IGF-IR可作为判断食管鳞癌的浸润、转移能力的有效指标,对食管癌的预后判断有一定的理论意义。

OBJECTIVE：To investigate the expression and correlation of IGF-I and IGF-IR in esophageal squamous cell carcinomar. METHODS： The expression of IGF- I and IGF-IR in was studied in tissues from cancer （n=49）,atypical hyperplasia epithelium （n = 19）, normal mucosa （n = 32） of the esophageal by SP immunohistochemistry. RESULTS： The positive rates of IGF-I were 34.4% （11/32）,52.6%（10/19） and 69.4% （34/49） in normal mucosa, atupical hyperplasia and cancer of the esophageal, respectively, P〈0.05. The positive rates of IGF--IR were 31.3% （10/32）, 52.6% （11/19） and 71.4% （35/49）, respectively, P〈0.05. The expression of IGF-I and IGF-IR correlated with LN（＋）,invasive depth and differentination. IGF-I expression was positively correlated with expression of IGF-IR. CONCLUSION： United examinig IGF- I and IGF-IR can become an objective target to evaluate potential power of invasion and lymph node metastasis of esophageal squamous cell carcinoma,it had a great significance to the judgement of prognosis in esophageal squamous cell carcinoma.